Ischemic Core and Penumbra in Human Stroke

Ischemic core and penumbra in human stroke.

BACKGROUND AND PURPOSE The ischemic core and penumbra have not been thoroughly characterized after acute cerebral thromboembolic occlusion in humans. Differentiation between areas of potentially viable and irreversibly injured ischemic tissue may facilitate assessment and treatment of stroke patients. METHODS Cerebral blood flow (CBF) was measured in 20 patients with acute middle cerebral art...

Sodium MRI of Core and Penumbra in ischemic stroke patients

Background and Purpose: Diffusionand perfusion-weighted imaging (DWI/PWI) of acute ischemic stroke can be used to identify the ischemic core (DWI) and to estimate the penumbral tissue (PWI-DWI mismatch) which is at risk of infarction but is potentially salvageable. MRI of sodium, a marker of ionic homeostasis that is disrupted after ischemia, within the lesion may be complementary by indicating...

Acute ischemic stroke: time, penumbra, and reperfusion.

Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain.

BACKGROUND AND PURPOSE Different strategies for neuroprotection of neonatal stroke may be required because the developing brain responds differently to hypoxia-ischemia than the mature brain. This study was designed to determine the role of caspase-dependent injury in the pathophysiology of pure focal cerebral ischemia in the immature brain. METHODS Postnatal day 7 rats were subjected to perm...

Cerebral blood flow threshold of ischemic penumbra and infarct core in acute ischemic stroke: a systematic review.

BACKGROUND AND PURPOSE Cerebral blood flow (CBF) reduction below critical thresholds discriminates between irreversible infarct core, penumbra, and benign oligemia (penumbra that recovers spontaneously). Thresholds are based on animal studies, and their diagnostic accuracy in humans has never been established. The purpose of this study was to assess the evidence available on CBF thresholds for ...